Hey everyone, a couple months ago I got my dna tested through https://www.23andme.com/  . Since birth, I have always thought that I was an alien. This was my chance to prove to my parents that I wasn't from this planet. Obviously, I am kidding, but I have always been curious about my genetics. I think its cool to find out where you came from and to find out what makes you different from everyone else. In addition, I was listening to a podcast with Dr Rhonda Patrick from foundmyfitness.com and she recommended getting your dna tested to see your certain risks for cancers. Now, I am only 23 years old and I certainly have not thought about getting cancer. However, Dr Patrick is 10 million times smarter then me so I figured it would be a good idea to order the DNA testing.

It is a very simple procedure. You go to the website, https://www.23andme.com/  and pay for one kit (200$). The price may seem steep, but it is worth it. Your dna is not going to change any time soon, so this is a one time payment. Plus, I think the prices are on the rise because just a couple months ago, mine only costed 99$. I would jump on this opportunity before the price continues to go up more. After you buy your kit, they will send you a kit in a couple day. Once you get the kit, you follow the instructions, spit in the tube and send it back. In about 5 to 8 weeks you will receive an email confirming your results are ready.  
 

This is a screenshot of the reports section from 23andme.com   

23andme does a great job at laying out your results and letting you know what your dna means to you. However, if you are a huge nerd like me and want to go much more in depth then head to http://www.snpedia.com/index.php/Promethease .  From there, you will upload your DNA data to their website; the cost is five dollars and is done in 20 minutes.  The website does a great job at instructing you what each thing means, so take your time and go over the instructions. Once you understand each aspect, then you can start doing some digging. It took me about two hours to find everything about myself, and here is what I came up with..

The Good

  • (worrier) advantage in memory and attention tasks- clear out dopamine slowly therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions 
  • You are not likely to experience hair loss before the age of 40.- 81% of male customers between the ages of 30 and 40 who are genetically similar to you have not experienced any hair loss.
  • Mix of muscle types. Likely sprinter.- alpha-actinin-3 deficiency appears to impair muscle performance. 
  • Higher vitamin B12 levels The reduced activity of the FUT2 enzyme with the A allele may decrease susceptibility to bacterial infection and indirectly lower the risk of vitamin B12 malabsorption, thereby resulting in higher vitamin B12 concentrations in A allele carriers.
  • Normal/Average risk for Alzheimer's
  • Optimistic and empathetic; handle stress well The one in four subjects who inherited a variation in this allele called G/G were significantly better at accurately reading the emotions of others by observing their faces than were the remaining three-quarters of subjects, who had inherited either a pair 
  • better odds of living to 100
  • normal fat metabolism

The Bad

  • 2.76x increased risk for Age Related Macular Degeneration.
  • Faster aging. Increased risk for Dementia. Less good cholesterol
  • increased proneness to anger
  • 2-4x higher risk of sun sensitivity if part of risk haplotype. Increased risk of sunburns and freckles instead of tanning.
  • impaired motor skills learning? On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning.
  • 5.5x risk type-1 diabetes- rs9272346 has been reported in a large study to be associated with type-1 diabetes.
  • 1.9x increased risk for CAD- rs1333049 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.
  • Lactose Intolerant
  • You have one short form 5-HTTLPR. You probably have one short-form 5-HTTLPR (serotonin-transporter-linked polymorphic region)- more likely for depression
  • More pain from social rejection
  • Less likely to live to 100. Unfortunately, this version of FOXO3 has reduced longevity. It has lower insulin sensitivity, increased oxidative stress, and increased risk of diabetes and heart disease.
  • reduced memory abilities- In a Swiss cohort: 'Carriers of KIBRA rs17070145 T allele had 24% better free recall performance 5 min after word presentation (P = 0.000004) and 19% better free recall performance 24 hours after word presentation
  • 3x increased testicular cancer risk for men
  • Reduced conversion of beta-carotene to retinol
  • higher odds of alcoholic liver disease, increased liver fat Alcohol seems to be 3x more damaging to your liver than typical. 5x higher risk for developing fatty liver, and 6x risk of fibrosis
  • increased risk for celiac disease
  • 2.5x risk for AMD; higher mortality among nonagenarians To minimize your risk of age related macular degeneration, consider a diet rich in vitamins C and E, lutein, zeaxanthin and the minerals zinc and copper, such as kale, spinach and broccoli.
  • altered drug metabolism and bioavailability; moderately increased risk for certain cancers- It mainly affects areas of the body that have a barrier or excretory function: blood-tissue barrier, the gastrointestinal tract, liver and kidney. Poor functioning of this cellular defense mechanism can affect elimination of carcinogens and movement of drugs in the system
  • somewhat lower vitamin D levels

 
Interesting ones

  • more stimulated by coffee You appear to have a common genotype in the gene CYP1A2 which metabolizes coffee more slowly than some other forms. The same amount of caffeine will tend to have more stimulating effect on slow metabolizers than on fast metabolizers.
  • Slow Caffeine Metabolizer. One copy of the slow caffeine metaboliser SNP, and one copy of the fast version. This makes you more strongly affected by drinking coffee, as caffeine is broken down slower in the liver. Supposedly this increases the risk of heart attacks, although other studies show caffeine is generally good for the heart. It also makes caffeine more effective at preventing Breast Cancer, Alzheimer's Disease, and Parkinson's disease. 
  • higher risk for nicotine dependence, lower risk for cocaine dependence
  • Possibly unable to taste bitter in some foods. Depending on your other SNPs, this might cause the inability to taste the bitterness of phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers). That would make cabbage etc. taste horribly bland and boring. On the other hand, fruit from the tropical bignay tree would taste unpleasantly bitter to you instead of sweet. You might eat less healthily.
  • increased susceptibility to novelty seeking less-efficient serotonin processing increased susceptibility to novelty seeking, may benefit from specific parenting techniques 
  • reduced MAOA activity- rs6323 (R297R / Arg297Arg) is a SNP in the MAOA (monoamine oxidase A) gene. Monoamine oxidase A degrades serotonin, dopamine, epineprine, and norepinephrine.
  • Probably MAOA 4 or 5 repeats: not Warrior Gene.People with this SNP usually also have either the 4 or 5 repeat (non-Warrior) version of MAOA which makes them less aggressive and less anti-social.
  • more able to detect β-ionone (floral) fragrance
  • you will lose 2.5x as much weight on a low fat diet- You are part of a group of 39% of all people
  • part of the 88% of the population claimed not to maintain weight loss unless you perform high energy exercise An interesting hypothesis, but not well validated, this patent is summarized in a simplified blog post and suggests a genotype to suggest diet and lifestyle changes which may be beneficial. 
  • You are likely to prefer salty or savory snacks. -71% of customers who are genetically similar to you prefer salty or savory snacks.

The Most Important Ones To Me

  • you will lose 2.5x as much weight on a low fat diet- You are part of a group of 39% of all people
  • increased susceptibility to novelty seeking less-efficient serotonin processing increased susceptibility to novelty seeking, may benefit from specific parenting techniques
  • more stimulated by coffee You appear to have a common genotype in the gene CYP1A2 which metabolizes coffee more slowly than some other forms. The same amount of caffeine will tend to have more stimulating effect on slow metabolizers than on fast metabolizers
  • You have one short form 5-HTTLPR. You probably have one short-form 5-HTTLPR (serotonin-transporter-linked polymorphic region)- more likely for depression
  • higher odds of alcoholic liver disease, increased liver fat Alcohol seems to be 3x more damaging to your liver than typical. 5x higher risk for developing fatty liver, and 6x risk of fibrosis
  • (worrier) advantage in memory and attention tasks- clear out dopamine slowly therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions 
  • You are not likely to experience hair loss before the age of 40.- 81% of male customers between the ages of 30 and 40 who are genetically similar to you have not experienced any hair loss.
  • Optimistic and empathetic; handle stress well The one in four subjects who inherited a variation in this allele called G/G were significantly better at accurately reading the emotions of others by observing their faces than were the remaining three-quarters of subjects, who had inherited either a pair 



 There were some pretty interesting things in that right? I would have never guessed that my body does better with a high carb diet versus a high fat diet.. Hooray pizza! Oh wait, I also have a predisposition to celiac disease... goodbye pizza =/.  Also, I found it very interesting how dangerous alcohol is for me, I am definitely going to reduce my binge drinking.  I think the coolest thing about the results were finding out that my body doesn't produce serotonin (happiness neurotransmitter) effectively. Now, I understand why I am so impulsive and constantly searching for rewards.

It is amazing to see how much our DNA effects us. By reading my results, you can get a pretty good idea of who I am and what careers I will pursue. This is just the beginning though. In the next 10 to 20 years DNA testing will be as common as getting your blood tested. Children will be getting tested, and we will have a better understanding of who they are before they even know it.  I understand this can be scary and some people feel that we have no right to do this. I see both points, but , I don't think you should be afraid of this information. Knowledge is power and every person has the right to know why they act a certain way. By knowing this information it gives you power because once you figure out the reason why, then we can solve the answer. 

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